Semaglutide is a synthetic agonist of the GLP-1 receptor (glucagon-like peptide-1), structurally derived from native human GLP-1 with 94% sequence homology. Its key structural modifications include the substitution of alanine at position 8 with 2-aminoisobutyric acid (Aib), as well as C18 acylation linked to lysine via a γGlu-mini-PEG dual-chain spacer.
These modifications give semaglutide marked enzymatic resistance to dipeptidyl peptidases (DPP-4) and high serum albumin affinity — parameters of interest in in vitro pharmacokinetic studies. This compound is used as a reference ligand in GLP-1R radiolabeling and receptor competition protocols.
CAS Number: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.6 g/mol
Format: Lyophilized powder — reconstitution required prior to analytical use
Purity: ≥ 98% (HPLC)
Storage: -20 °C
COA: Available / link on this page
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